Location and effect of procaine on lecithin/cholesterol membranes using X-ray diffraction methods
Identifieur interne : 00E152 ( Main/Exploration ); précédent : 00E151; suivant : 00E153Location and effect of procaine on lecithin/cholesterol membranes using X-ray diffraction methods
Auteurs : H. G. L. Coster [Australie] ; V. J. James [Australie] ; C. Berthet [France] ; A. Miller [France]Source :
- BBA - Biomembranes [ 0005-2736 ] ; 1981.
Descripteurs français
- Wicri :
- topic : Région polaire.
English descriptors
- KwdEn :
- Acta, Acyl chains, Anesthetic, Average spacing, Bilayer, Bimolecular lipid membranes, Biophysica acta, Diffraction patterns, Electron densities, Hormonal specificity, Lecithin/cholesterol multilayer, Lipid, Lipid bilayer, Lipid membranes, Membrane, Meridional direction, Personal communication, Polar region, Procaine, Procaine molecules, Reference lists, X-ray diffraction.
- Teeft :
Abstract
Abstract: X-ray diffraction studies were made on lecithin/cholesterol multilayers with very high water content and containing the local anaesthetic procaine. Narrow-angle diffraction experiments show that the procaine molecules are located with the uncharged aromatic amine group approx. 10 Å from the centre of the bilayer. The polar tertiary amine group of these molecules is almost certainly located in the polar head-group region of the membrane. Wide-angle diffraction experiments show that the incorporation of procaine molecules into such lipid membranes produces an approx. 30% increase in the spread of acyl chain separation, although the average spacing between the chains is slightly reduced.
Url:
DOI: 10.1016/0005-2736(81)90593-9
Affiliations:
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Le document en format XML
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Berthet</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>European Molecular Biology Laboratory, C.E.N.G., L.M.A. 85X</wicri:regionArea><wicri:noRegion>L.M.A. 85X</wicri:noRegion><wicri:noRegion>L.M.A. 85X</wicri:noRegion></affiliation></author><author><name sortKey="Miller, A" sort="Miller, A" uniqKey="Miller A" first="A." last="Miller">A. 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Narrow-angle diffraction experiments show that the procaine molecules are located with the uncharged aromatic amine group approx. 10 Å from the centre of the bilayer. The polar tertiary amine group of these molecules is almost certainly located in the polar head-group region of the membrane. Wide-angle diffraction experiments show that the incorporation of procaine molecules into such lipid membranes produces an approx. 30% increase in the spread of acyl chain separation, although the average spacing between the chains is slightly reduced.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Coster, H G L" sort="Coster, H G L" uniqKey="Coster H" first="H. G. L." last="Coster">H. G. L. Coster</name></noRegion><name sortKey="James, V J" sort="James, V J" uniqKey="James V" first="V. J." last="James">V. J. James</name></country><country name="France"><noRegion><name sortKey="Berthet, C" sort="Berthet, C" uniqKey="Berthet C" first="C." last="Berthet">C. Berthet</name></noRegion><name sortKey="Miller, A" sort="Miller, A" uniqKey="Miller A" first="A." last="Miller">A. Miller</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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